DIPMOL RANGE

DIPMOL –SR ( S.R. Diclofinac Sodium )

Mechanism of Action -:

It belongs to Non Steroidal Anti- inflammatory group of Drugs (NSAID’S)

Diclofinac is Aryl – Acetic acid derivative & a non selective Cox inhibitor i.e.- conventional NSAID’S.

It has analgesic – antipyretic & anti-inflammatory action.

It inhibits Prostaglandin synthesis and has short lasting antiplatelet action.

Pharmacokinetics -:

It is well absorbed orally.

99% Protein bound, metabolized and excreted bothin urine and bile.

Plasma 1/2life is 2 hours.

It has good tissue penetrability and concentration in synovial fluid is maintained for 3 times longer period than in plasma, exerting extended therapeutic action in Joints.

Adverse effects -:

Adverse effects are generally mild.

They may include epigastric pain, nausea, headache, dizziness & rashes.

Gastric ulceration & bleeding are less common.

Reversible elevation of serum aminotransferase can occur kidney damage in rare.

Contraindications-:

Active Peptic ulcer.

Hypersensitivity to Diclofinac or other NSAID’S.

Interactions -:

It increases Blood levels of Lithium & Digoxin.

It increases toxicity of methoprexate.

It potentiates potassium sparing diuretics but inhibits other diuretics.

It’s antiplatelet action increases the risk of bleeding in patients on oral anticoagulants.

INDICATIONS (USES) -:

DICLOFINAC IS AMONG THE MOST EXTENSIVELY USED NSAID’S EMPLOYED IN,

RHEUMATOID ARTHRITIS

OSTEOARTHRITIS

BURSITIS

ANKYLOSING SPONDYLITIS

MUSCOSKELETAL CONDITIONS

LOW BACK PAIN

DYSMENORRHOEA

POST – TRAUMATIC PAIN

DENTAL PAIN

INFLAMMATORY CONDITIONS

DIPMOL –P ( Diclofinac Sodium + Paracetamol )

PARACETAMOL

Paracetamol is Para-aminophenol derivative.

It has good analgesic & antipyretic action with poor anti-inflammatory action.

Pharmacokinetics -:

Paracetamol is well absorbed orally.

Only about 1/3^rd is Protein bound in plasma and it is uniformally distributed in the body.

It is conjugated with Glucuronic acid and sulfate and is excreted rapidly in urine.

Plasma ½ life is 2-3 hours.

Adverse effects -:

Usually safe & well tolerated.

Nausea & rashes occur occasionally Leucopenia is very rare.

May cause allergic reactions or blood dyscrasias.

Analgesic nephropathy occurs after ingestion of high doses for years.

Acute paracetamol poisoning occurs in specially small children who have hepatic glucuronide conjugation.

Contraindications -:

Hypersensitivity to the Drug.

Not recommended in premature Infants <2kg.

Interactions -:

It does not have significant Drug interactions.

May increase the risk of Liver damage in chronic alcoholics.

INDICATIONS (USES) -:

One of the most commonly used over the Counter analgesic for HEADACHE, MUSCULOSKELETAL PAIN, DYSMENORRHOEA ETC. Where anti-inflammatory action is not required.

It is one of the Drug available to be used as ANTIPYRETIC.

It is much safer than Aspirin in terms of Gastric irritation, Ulceration & Bleeding (can be given to Ulcer Patients) and it does not prolong the Bleeding time.

Can be used in all Age group, Pregnant and Lactating women & in Patients in whom Aspirin is contraindicated.

DIPMOL –MR ( Diclofinac Sodium+Paracetamol+Chlorzoxzone)

CHLORZOXAZONE

Chlorzoxazone belongs to Mephenesin group of Centrally Acting muscle relaxants.

These Drugs reduce skeletal muscle tone by a selective action in Cerebrospinal axis without altering Consciousness.

It selectively depresses Spinal & Supraspinal polysynaptic reflexes involved in regulation of Muscle tone.

It also has some sedative property.

Adverse effects -:

Angioedema & Anaphylactoid reactions like,

Drowsiness

Dizziness

G.I disturbances

Restlessness

Irritability

Skin rashes

Liver damage are also reported.

INDICATIONS (USES) -:

ACUTE MUSCLE SPASM

TORTICOLLIS

BACKACHE

NEURALGIA

AS AN ADJUNCT TO NSAID’S

DIPMOL –SP ( Diclofinac Sodium+Paracetamol+Serratiopeptidase)

SERRATIOPEPTIDASE

It is an Anti-inflammatory Enzyme.

It is a Proteolytic enzyme obtained from Serratia spp.

When taken orally it helps in relieving Inflammation & Edema associated with trauma infection or Chronic Venous Insufficiency.

Adverse effects -:

Nausea

Anorexia

Gastric discomfort

Epestaxis

Hypersensitivity may occur rarely.

Contraindications -:

Hypersensitivity to Drug

Bleeding disorders

INDICATIONS (USES) -:

As an adjunct in treating INFLAMMATION and EDEMA associated with,

SURGERY

ACCIDENTAL TRAUMA

ACUTE & CHRONIC SINUSITIS

OTITIS MEDIA

BREAST ENGORGEMENT

DENTAL INFECTIONS & ALVEOLAR ABCESS

TO FACILITATE EXPECTORATION IN BRONCHITIS & LUNG INFECTION